The Nintendo DS version of MySims takes place in a vacation resort with the player tasked with the job of luring in tourists. This is accomplished by doing tasks for the locals who lives in your town and after you're done with a certain task you earn stars. Players collect stars to unlock other parts of the city as well as new minigames and new items in stores. As more stars are collected, the town grows and mini games are unlocked.
You can also interact with tourist and these tourist have different moods like sad, normal, or mad. You must cheer the tourist up with many different options that are available in the game. If you succeed on making the person happy, you can earn some simoleans or on business townsfolk you can progress through the story. You can play certain minigames and depends how you do, you earn more money and more points that you can earn and eventually if you play the game many times, you can unlock new difficulties of those minigames. You can also customize T-shirts and furniture from the different locals and you can customize your house or mansion. You can also change your person's style in any different way in the wardrobe and you can store items in the drawer.
The Nintendo DS version of MySims supports touch screen and microphone functionality. The touch screen is used for talking and movement as well as placing and moving furniture. Other buttons may control specific tasks such as taking photos or initiating conversation.